MOSFET device consists of P-type Si semiconducting material substrate with a insulating oxide bed between it and a metal gate. REF
The overall clip from puting up to geting consequences is much shorter. However, there is non much difference in it dose truth compared to other dosimetry tools in usage. ( cite 3 ) .
When an ionising radiation is exposed to MOSFET, electron-holes are generated within the Si dioxide bed. The junction potency produced causes electron to migrate to the Gatess while holes move towards oxide silicon interface. Some of the holes the holes are trapped doing a negative displacement in gate electromotive force. The electromotive force at which a displacement can be induced is known as the threshold electromotive force. The threshold electromotive force doing the displacement is straight relative to the radiation dosage absorbed by the metal oxide bed. Temperature does affects the map of the device as it influences the threshold electromotive force, nevertheless this intervention by temperature can be combated by the usage of two MOSFET one measures the threshold electromotive force before irradiation and the other after the irradiation and at the same temperature. By so making a rectification factor for temperature will non be needed in the concluding reading. The device used is the double prejudice MOSFET. ( Reference 2 ) .
( Rajesh et al ) conducted a survey to gauge the tegument dosage of patient being treated with tomotherapy. Two caput and cervix patients were selected for this survey. The first with carcinoma of the nasopharynx with intracranial extension and multiple cervical adenopathy. Second patient was diagnosed with carcinoma of buccal mucous membrane pit. The MOSFET sensors were placed on the tegument inside the mask with a tape with TLD besides placed beside the MOSFET and safeguard taken to keep the same location of the sensors for subsequent fraction in a hebdomad. The tegument dosage was measured for i¬?ve back-to-back fractions utilizing both MOSFET and TLD. For the first patient the MOSFET measured the tegument dosage as 90 % while TLD read 92 % of the prescription dosage ( 2.2Gy ) . The fluctuation between tegument dosage measured with MOSFET and TLD was 2.2 % . For the 2nd patient the tegument dosage measured with MOSFET and TLD was 88 % and 86 % of the prescription dosage, severally. A fluctuation of 2.3 % was observed between tegument dosage measured with MOSFET and TLD. This consequence showed there are great similarities between TLD and the MOSFET. The difference in the consequences was attributed to discrepancy in the tomotherapy intervention planning system used, given a less than accurate value for the tegument dosage to the patient which when corrected may do the dosimetry read-out more accurate. However, the complex nature of puting up and obtaining read-out makes the MOSFET a more favorable option. This survey though, had a sample of two patients which is instead little and the figure of reading taken over the period of the test is non a good representation of the whole intervention period. A more varied sample should hold been used which a sample of two does n’t supply.
The benefits of MOSFET supersedes other solid province dosimetric techniques available, the standardization process is simple compared to TLD and besides easy to maintenance and operation. The MOSFET is a non-intrusive semiconducting material radiation dosemeter which enable direct and simple read-out of the dosage. This technique has a batch in common with semi music director rectifying tube. The usage of metal oxide semiconducting material field consequence transistors ( MOSFET ) are being applied in more radiotherapy Centres for mensurating absorbed dose. This is a really good option to the thermoluminescence ( TLD ) as it eliminates the short approach of ( TLD ) ‘s and improves upon the dosimetric techniques being used.
One noteworthy disadvantage of MOSFET dosimetry is its limited life span where the one-dimensionality of the sensor decreases after a big dose accretion, therefore necessitating a larger dosage for the same possible difference. However, ( Peter and butson ) found that the clinical semiconducting material dosimetry system ( CSDS ) MOSFET dosimetry system provides an equal dosage appraisal at low dosage degrees, with an probe conducted utilizing a new MOSFET system realised an addition in the truth of low dose readings. This was carried out utilizing a high-energy X raies produced by a pulsed radiation additive gas pedal. It was noticed that by using this process the life span of the MOSFET can be prolonged without impacting the truth of consequences.
The usage of a micro-MOSFET as dosemeter in vivo for intraoperative external radiation therapy ( IOERT ) has proved positive, supplying its preciseness around 4 % . ( Ciocca et al ) . With Precision of MOSFET being 0.7 % 1SD for and that of rectifying tubes 0.05 % . the truth of MOSFET is lower compared to rectifying tubes ( Jornet et al ) . nevertheless it other favorable advantage makes is a better tool than rectifying tube besides the truth of MOSFET although lower than rectifying tube is really acceptable for clinical usage.
Semiconductors rectifying tubes are one of the few established agencies of radiation therapy dosimetry. The feasibleness of it usage and truth has been tested and proven over the old ages. Semiconductor rectifying tubes are normally silicon, p-n junction rectifying tubes. Electron holes are created during irradiation of the rectifying tube, charge bearers move across the electromotive force to recombine with electron hole. Current is therefore generated which flows in the rearward way to the rectifying tube current flow. The popularity of the semiconducting material rectifying tube is due chiefly to its ; high sensitiveness with comparing to ionisation chamber as the criterion, real-time read out, and simple execution.
It has a little size, high-quality mechanical stableness, absence of external electromotive force, and instant handiness of the measured dosage. ( Esser and Mijnheer )
Temperature and force per unit area adjustment uncertainness of the additive gas pedal dosage proctor due to leakage in the chamber ; incorrect overseas telegram connexion to the unit that could electronically alter the dosage proctor for force per unit area and temperature and inaccuracies in the planning system. ( Nilsson et al )
Semiconductor rectifying tube is besides really utile for taking both entry and issue dosage during in vivo dosimetry. ( Rodica et al ) .
However, with all the benefits of the semiconducting materials it does hold it drawbacks
( I ) The addition in intervention clip due to the clip needed to place the rectifying tube on the
patient. ( two ) Diodes act as a buildup stuff and therefore increase the tegument dosage ( 18 ) . ( three ) If used for entryway dosage measurings, rectifying tubes attenuate the primary beam ( 18 ) . ( four )
For practical grounds, merely really limited Numberss of rectifying tubes are used for coincident measurings. ( V ) In order to find the midline dosage, both entryway and issue dosage measurings have to be performed. EDIT. ( kasper et Al ) .
Sensitivity of semiconducting material affected by temperature hence, a factor has to be incorporated in it standardization, the temperature fluctuation is besides dependent on dosage received by the rectifying tube. Diodes required for entry dose dosimetry are topographic point on the patient perchance, ensuing in temperature alteration in the rectifying tube normally to room temperature and could lift to about 10 grades C, this has made it necessary to include a rectification factor as this consequence can change the sensitiveness of the rectifying tube. Significant alterations in sensitiveness do occur after the first irradiation, many rectifying tubes are hence irradiated to get the better of initial alteration in sensitiveness before standardization. However, the usage of rectifying tube for negatron dosimetry is non widely accepted and assorted research and experiment have been conducted sing the issue. REF
A survey conducted by ( Lee et Al ) realised some uncertainnesss in the measuring of the rectifying tube notably, the duplicability of the mark dosage measured was merely 7 % .
( Li C et al quotation mark ) , suggest “ due to the important decrease of rectifying tube system sensitiveness with big cumulative dosage, a rectifying tube system in the present constellation is non fit for supervising intervention machine dosage end product, neither should in vivo rectifying tube dosimetry measurings be used for negatron beams, due to the important disturbance of deepness dosage characteristics by the sensors placed on the beam-entrance surface, particularly for beam energies less than 9 MeV ”
However, ( RAVINDRA YAPARPALVI et Al ) thinks diode dosimetry is an indispensable tool for verifying truth of dosage delivered in negatron beam intervention but might ensue in decrease of dosage to aim volume due to fading of beam.
An probe examined the issues associated with in vivo dosimetry in chest irradiation and the signii¬?cance of mistake in arrangement of the rectifying tube sensors showed due to the changing contour of the chest throughout the intervention volume and the consequence of the usage of cuneus compensators on the off-axis part, a significant mistake is possible. ( Herbert et Al ) . Besides some trouble in placement of the rectifying tubes on the patient, peculiarly in the caput and neck country.
( Noel et al ) conducted a survey affecting 7519 patients over 5 old ages were checked by in vivo dosimetry following a protocol to observe any systematic mistake that may hold been missed during other cheques performed at the assorted phases of planning and computation before the beginning intervention session. The consequences showed that 79 mistakes were detected, half of which could hold induced a fluctuation of more than 10 % in the dosage delivered. Except for the dislocation of the Co unit used during irradiation, 78 out of 79 mistakes were of human beginning.
These tax write-offs were made from the survey ; dose delivered to patient by in vivo dosimetry for radiation therapy intervention is an indispensable facet of a quality confidence programme and with less trouble. In vivo dosimetry performed on patients can give us information on the efficiency of a medical gas pedal. They largely arise during the intervention be aftering measure. Mistakes are normally made during informations transportation by ; entering mistakes when composing down informations and missed informations.
These errors can be serious if they are non detected at the initial phase of intervention of intervention since they could be systematic. In vivo dosimetry is a really efficient technique for observing mistakes that can happen during
the class of a radiation therapy intervention. The usage of Si rectifying tubes, allows the direct measuring of consequences therefore, an immediate action can be taken to relieve mistakes detected during the of intervention of the patient. Most of the detected mistakes were down to human and analytical mistake of the consequences taking to the intuition that random mistakes were common in radiation therapy. In order to root out some of these systematic mistakes computerized record and verify system were incorporated in their quality confidence programme. Even with these steps in topographic point mistakes can still happen therefore the importance of utilizing in vivo dosimetry in order to formalize the dose bringing.
A survey conducted by ( Lanson et al ) to look into the demand for in vivo dosimetry during radiation therapy and to besides measure the systematic and random mistakes found during in vivo dosimetry. The survey took topographic point 1993 and 1997, utilizing semiconducting material rectifying tube for dosage affecting 378 patients being treated at assorted sites.
The result of the survey showed the demand for in vivo dosimetry patient having radiation therapy. This process will necessitate a set protocol which will besides assist extinguish systematic mistake in computation of dosage or dose bringing. Mistake was recorded in approximately 9 % of the instances which is unbearable. They established that the deficiency of in vivo dosimetry mistakes may happen due to undetected systematic mistakes. The rectification of these mistakes will take to betterment in intervention. For these mistakes to be eliminated an accurate in vivo dosimetry is required with Stable and accurate measuring. Calibration of the dosimetry tool and frequent quality confidence of the tool is besides indispensable to guarantee its operation at optimal. For these mistakes to be eliminated an accurate in vivo dosimetry is required with stable and accurate measuring. Calibration of the dosimetry tool and frequent quality confidence of the tool is besides indispensable to guarantee its operation at optimum.
In vivo dosimetry during conformal radiation therapy Requirements for and A®ndings of a everyday process J.H. Lanson* , M. Essers
1, G.J. Meijer, A.W.H. Minken, G.J. Uiterwaal, B.J. Mijnheer
TLD ‘s exploits the belongingss of certain stuffs to hive away a fraction of energy they absorb. In radiation therapy the TLD used is Lithuim Fluoride doped with Magnesium and Ti ( LiF: MgTi ) . In this sense the dosimetry energy released by ionization radiation is absorbed by TLD and released in the signifier of optical radiation when aroused negatron return to the land province after absorbing energy. Electrons absorb sufficient energy to get away from their lattices, a passage occurs to return the negatron to it land province. This procedure is known as the thermoluminescence. The energy released in the signifier of photon on return to it land province is noticeable by a photomultiplier tubing. The end product of the photomultiplier is relative to the energy originally absorbed. The luminescence of the TLD is straight relative to the dosage accumulated by the TLD stuff. ( mangili et Al ) . TLD ‘s do non hold signii¬?cant directional dependance and does non necessitate temperature and force per unit area corrections. ( Izewska and Rajan ) .
The usage of TLD requires tempering of the device which involves the warming of the TLD for a drawn-out clip at temperature greater than one the reading was made and so chilling at room temperature, this process is required to take residuary signal thereby guaranting optimal sensitiveness, this is to guarantee TLD has precisely the same belongingss before irradiation. ( A.J.J. Bos ) .
The chief advantages of rectifying tube dosimetry are their instantaneous response and their easiness of usage by the healers. ( Doracy et al )
A survey conducted by ( Gustavo L. Barbi et Al ) utilizing 45 thermoluminescent dosemeters ( TLD ) divided into two batches a Co -60 unit was used to enlighten the TLD ‘s. 11 caput and cervix patients were indiscriminately selected to take portion in the survey.
The expected dosage was defined as the dosage at the deepness of dose upper limit and was calculated manually from the prescribed tumour dosage ( Van Dam and Marinello, 1994 ) . The first batch was found to be within -/+1.5 % of the expected dosage and the 2nd batch -/+1.6 % of the expected manually calculated dosage. The inaccuracy was attributed to discrepancy in the dosimetric system. It was concluded that the
thermoluminescent dosimetric system for executing in vivo entryway dosage measurings in external photon beam radiation therapy presented good consequences.
The consequences obtained demonstrated the value of thermoluminescent dosimetry as a intervention dose confirmation method and its pertinence as a dosimetry tool in radiation therapy. ( Alessandro et al )
A research was conducted by ( Amor Duch et Al ) to mensurate dose distributed during entire organic structure irradiation utilizing thermoluminescence dosimetry. A dosage of 2.25Gy was given twice a twenty-four hours for three yearss. The TLD system described was proven to be suited for in vivo dosimetry in entire organic structure irradiations within an uncertainness of 2 % even in heterogenous countries of the organic structure and when lung shielding blocks are applied. However, to achieve this degree of truth, it is necessary to utilize single standardization factors, a temporal sensitiveness control and standardization conditions every bit near as possible to irradiation conditions. The consequences the difi¬?culty of graduating an in vivo dosimetry system when lung shielding blocks are in topographic point, due to the difi¬?culty in obtaining mention dosage measurings in the tissue. The standardization experiments indicated that in a high dosage gradient part, standard standardization is non valid and therefore mistakes in dose appraisal from the mention ionisation chamber can be made. Furthermore, it is shown that TLDs in an anthropomorphous apparition can be a utile to prove any non-standard therapeutical technique. A better cognition of the radiation beam and of the sensor response would be necessary to determine the best standardization set-up.
TLD ‘s have proved to be really practical in complicated geometries where best usage could be made of the advantages of TLD dosemeters such as their base entirely character and their little physical size ( Tomas et al ) . TLD fast read out clip and ability to be used in more complicated geometry is an advantage over semiconducting materials
Dosimetric truth at the degree of 5 % , is understood today to stand for a tolerance of divergence between the response of tumor and healthy tissue, is postulated in dosimetric protocols ( TRS 398, 2000 ) .
A clinically acceptable preciseness in dose measuring of rectifying tubes is achieved when the necessary factors act uponing the rectifying tube response are quantified against an ionisation chamber holding a traceable standardization ( Doracy et al ) . nevertheless,
when larger rotational mistakes are non taken into history, it leads to a reduced truth in dose measuring. ( Remeijer et al ) . There has been greater involvement in phantom TLD dosimetry outside the intervention i¬?eld, to find the unwanted doses in radiation therapy, chiefly for appraisal of hazard of secondary malignant neoplastic diseases ( Harrison, 2007 ) .
3.1.4 Veridose rectifying tube dosimetry
A survey was conducted by ( Ali et al ) to look into
The usage of veridose rectifying tube as an option for semiconducting material rectifying tube, the consequences of the survey showed survey was similarity in consequence with measuring taken by calibrate ion chamber at the same time.
The design of these rectifying tubes used are made to let for easy patient set up, as it has a hemispherical form, which is easy to put on the tegument of patients.
Construct up stuffs was attached to the rectifying tube ; the importance of this is to enable the rectifying tube step the beam at the point of upper limit dosage. Assorted thickness of stuffs are used for single rectifying tubes with regard to the beam energy to be measured. The veridose system can besides be used for negatron beams and besides requires construct up stuff for assorted negatron energies.
The purpose of this survey was measure the one-dimensionality, truth, duplicability, energy dependance and orientation of the system.
The energy absorbed by both photons and negatron rectifying tubes were measured to find the energy dependance of veridose.
Dose absorbed by the veridose rectifying tube was compared to the dosage measured by the ionization chamber in H2O apparition. The consequence showed a difference of less than 4 % and 3 % for both negatron and photon rectifying tubes severally compared to the ion chamber.
A 12.5 % dose disturbance was recorded for veridose rectifying tubes compared to the 25 % dose disturbance in semiconducting material rectifying tubes at 6Mev negatron beam
Doses of 10cGy showed less than 5 % nonlinearity, conversely, nonlinearity increased with diminishing dosage of less thant 10cGy in the negatron rectifying tube. Hence requires cautious standardization for dose below 10cGy
The result showed less than 2 % alteration for beams between 6-20MV. Other rectifying tubes had a 30 % alteration with beam energies between 6-20MV
They suggested that different rectifying tube be used for assorted beam energies degrees.
It was realised that the veridose rectifying tube is a good option for semiconducting material rectifying tubes as it, improves on their overall benefits
Veridose is therefore an acceptable device for clinical usage as it exhibits high one-dimensionality, duplicability and really good truth. It compatibility with additive gas pedal was besides established
Literature on this technique is nevertheless far and between and more research demand to be done to corroborate it viability as a clinical tool.